Rabbit Anti-URG4/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-URG4/FITC Conjugated antibody

FLJ20654; HBV X protein up-regulated gene 4 protein; HBV X protein upregulated gene 4 protein; HBxAg up-regulated gene 4 protein; HBxAg upregulated gene 4 protein; KIAA1507; Up-regulator of cell proliferation; Upregulated gene 4; Upregulator of cell proli

Cat:

SL2171R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human URG4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

105kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008]

Function:
May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.

Subcellular Location:
Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.

Tissue Specificity:
Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.

Database links:

Entrez Gene: 55665 Human

Omim: 610337 Human

SwissProt: Q8TCY9 Human

Unigene: 709317 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

HBx是HBV感染、复制、发病和可能致癌关键蛋白,是具有多种功能的病毒调节因子,在慢性HBV感染的病程中占有举足轻重的作用。URG4(Upregulated gene 4)也是一个从肝癌细胞中克隆出来的可以被HBx蛋白上调的新分子，URG4过量表达在乙型肝炎感染和肝癌细胞中。

Product Feedback Wall