Rabbit Anti-DDB1/FITC Conjugated antibody

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DNA damage-binding protein 1; DDB1; DDB-1; ;Damage specific DNA binding protein 1; DDB 1; DDB p127 subunit; DDBa; DNA damage binding protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV-DDB1; X associated protein 1; XAP

Cat:

SL2588R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human DDB1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

125kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. [provided by RefSeq].

Subunit:
Component of the USLVDDB complex which includes DDB1 and DDB2.

Subcellular Location:
Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV irradiation and subsequently accumulates at sites of DNA damage.

Similarity:
Belongs to the DDB1 family.

Database links:

Entrez Gene: 511951 Cow

Entrez Gene: 100290337 Human

Entrez Gene: 1642 Human

Entrez Gene: 13194 Mouse

Entrez Gene: 64470 Rat

Omim: 600045 Human

SwissProt: A1A4K3 Cow

SwissProt: Q16531 Human

SwissProt: Q3U1J4 Mouse

SwissProt: Q9ESW0 Rat

Unigene: 290758 Human

Unigene: 289915 Mouse

Unigene: 466856 Mouse

Unigene: 1682 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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