background:
IGSF8 is a 65kDa single-pass membrane protein that may play a key role in many of the functions attributed to CD81 and CD9, like Hepatitis C infection and oocyte fertilization. It is also believed that this protein acts as a negative regulator of cell motility (e.g. T-cell mobility, prostate cancer cell migration) and is involved in the regulation of neurite outgrowth and maintenance of the neural network in the brain.
Function:
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Subunit:
Interacts directly with CD82 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1. Interacts with CD81/tetraspanin-28.
Subcellular Location:
Cell membrane; Single-pass membrane protein.
Tissue Specificity:
Expressed in lymphocytes as well as in many tissues with higher expression in brain. Detected in all regions of the brain with weak expression in the pituitary. Expressed selectively by neurons but not by glial cells.
Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 93185 Human
Entrez Gene: 140559 Mouse
Omim: 606644 Human
SwissProt: Q969P0 Human
SwissProt: Q8R366 Mouse
Unigene: 36412 Human
Unigene: 271717 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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