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Rabbit Anti-ICOS/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.[provided by RefSeq, Jul 2008].
Function:
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
Subunit:
Homodimer; disulfide-linked.
Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein (Potential).Isoform 2: Secreted (Potential).
Tissue Specificity:
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Post-translational modifications:
N-glycosylated.
DISEASE:
Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1) [MIM:607594]. CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo.
Similarity:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Database links:
Entrez Gene: 29851 Human
Entrez Gene: 54167 Mouse
Entrez Gene: 64545 Rat
Omim: 604558 Human
SwissProt: Q9Y6W8 Human
SwissProt: Q9WVS0 Mouse
SwissProt: Q9R1T7 Rat
Unigene: 56247 Human
Unigene: 42044 Mouse
Unigene: 168816 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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