Rabbit Anti-Granzyme B + D + E + N + G + F + H/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Granzyme B + D + E + N + G + F + H/FITC Conjugated antibody

Granzyme D/B/E/N/G/F/H; Granzyme D; Granzyme B; Granzyme E; Granzyme N; Granzyme G; Granzyme F; Granzyme H; Cathepsin G-like 2; CCP-X; CCP3; CCP4; CCP5; CGL-2; CSP-C; Ctla-5; Ctla-6;, Ctla-7; CTLA1; CTSGL2; Grz d; Grz e; Grz f; Grz g; GZMD; Gzme; Gzmf; Gz

Cat:

SL2579R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Granzyme B

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

28kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
protease required for lymphocyte cytotoxic granules to lyse target cells [RGD].
Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.

Function:
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Subcellular Location:
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Similarity:
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.

Database links:

Entrez Gene: 3002 Human

Entrez Gene: 14939 Mouse

Entrez Gene: 171528 Rat

Omim: 123910 Human

SwissProt: P10144 Human

SwissProt: P04187 Mouse

SwissProt: P18291 Rat

Unigene: 1051 Human

Unigene: 14874 Mouse

Unigene: 132115 Rat

Unigene: 145789 Rat

Unigene: 21395 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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