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Rabbit Anti-Granzyme A/FITC Conjugated antibody
background:
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Function:
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis.
Subunit:
Homodimer; disulfide-linked. Interacts with APEX1.
Subcellular Location:
Isoform alpha: Secreted. Cytoplasmic granule.
Similarity:
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
Database links:
Entrez Gene: 3001 Human
Omim: 140050 Human
SwissProt: P12544 Human
Unigene: 90708 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GzmA是存在于细胞毒性T淋巴细胞(CTL)和自然杀伤细胞(NK细胞)的细胞毒颗粒中含量最多的一种丝氨酸蛋白酶。
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