Rabbit Anti-GNLY/FITC Conjugated antibody

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Granulysin; D2S69E; LAG2; 519; LAG 2; Lymphocyte activation gene 2; Lymphokine LAG 2; NKG 5; NKG5; Protein NKG5; T cell activation protein 519; T lymphocyte activation gene 519; TLA519.

Cat:

SL2577R-FITC

Species Reactivity：

Human,

Immunogen：

KLH conjugated synthetic peptide derived from human GNLY/NKG5

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

14kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].

Function:
Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.

Subcellular Location:
Secreted. Note=Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.

Tissue Specificity:
Expressed in natural killer and T-cells.

Post-translational modifications:
A 9 kDa form is produced by proteolytic processing of a 15 kDa protein.

Similarity:
Contains 1 saposin B-type domain.

Database links:

Entrez Gene: 10578 Human

Omim: 188855 Human

SwissProt: P22749 Human

Unigene: 105806 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

granulysin是近年来新发现的一种细胞毒性效应蛋白,是由激活的细胞毒性T淋巴细胞(cytotoxic T lymphocytes, CTL)和自然杀伤细胞(natural killer, NK)产生的一种阳离子蛋白质.能够杀伤微生物和肿瘤细胞.

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