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Rabbit Anti-CD226/FITC Conjugated antibody
background:
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the SLVset. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
Subunit:
Interacts with PVR and PVRL2.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Expressed by peripheral blood T-lymphocytes.
Similarity:
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 10666 Human
Omim: 605397 Human
SwissProt: Q15762 Human
Unigene: 660130 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD226分子是一种广泛表达于多种免疫细胞膜表面的Ⅰ型跨膜糖蛋白,CD226广泛表达于T细胞、NK细胞、NK T细胞、活化的血管内皮细胞、巨核/血小板谱系、单核细胞、胸腺细胞、某些B细胞亚群、部分造血干细胞和肥大细胞等免疫细胞表面,在免疫系统以外则分布于海马和小脑皮质的神经突触部位。CD226与其配体的相互作用参与CTL和NK细胞的活化、分化和细胞毒作用,调节CD4+ T细胞的增殖和分化,介导内皮细胞与其他细胞的黏附,促进血小板的活化与聚集,参与造血调控,介导肥大细胞的脱颗粒作用,参与NK T细胞和胸腺细胞的抗凋亡作用、树突状细胞的成熟、免疫突触和神经突触的形成,并与肿瘤、自身免疫性疾病、移植排斥及病毒感染等疾病密切相关。
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