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Rabbit Anti-CXCL5/FITC Conjugated antibody
background:
The protein encoded by this gene is an inflammatory chemokine that belongs to the CXC chemokine family. This chemokine is produced concomitantly with interleukin-8 (IL8) in response to stimulation with either interleukin-1 (IL1) or tumor necrosis factor-alpha (TNFA). This chemokine is a potent chemotaxin involved in neutrophil activation. [provided by RefSeq].
Function:
May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation.
Subcellular Location:
Secreted.
Post-translational modifications:
GCP-2(1-78) and GCP-2(9-78) are produced by proteolytic cleavage after secretion from fibroblasts and epithelial cells. GCP-2(9-78) is the most prominent form. A number of additional N-terminal (processed between pos. 41 and 48) and SLCterminal (processed between pos. 118 and 132) processed forms have been identified, probably also representing intermediate states.
Similarity:
Belongs to the intercrine alpha (chemokine CxC) family.
Database links:
Entrez Gene: 6374 Human
Entrez Gene: 20311 Mouse
Omim: 600324 Human
SwissProt: P42830 Human
SwissProt: P50228 Mouse
Unigene: 89714 Human
Unigene: 4660 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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