Rabbit Anti-CLEC2/FITC Conjugated antibody

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C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CLEC 2; CLEC 2B; CLEC-2; CLEC2; CLEC2B; PRO1384; QDED721

Cat:

SL2543R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human CLEC2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

27kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Natural killer (NK) cells express multiple calcium-dependent (SLCtype) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a SLCtype lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

Function:
Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLSLCgamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HISLV1) and facilitates its capture by platelets.

Subunit:
Homodimer.

Subcellular Location:
Membrane; Single-pass type II membrane protein (Probable).

Tissue Specificity:
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.

Post-translational modifications:
Glycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding.

Similarity:
Contains 1 SLCtype lectin domain.

Database links:

Entrez Gene: 51266 Human

Omim: 606783 Human

SwissProt: Q9P126 Human

Unigene: 221418 Human

Unigene: 409794 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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