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Home > Product > Antibody > Rabbit Anti-Versican/FITC Conjugated antibody
Versican; CSPG2; DKFZp686K06110; ERVR; GHAP; PG-M; WGN; WGN1; versican core protein isoform 1 precursor; ; Large fibroblast proteoglycan; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; CSPG2; Glial hyaluronate binding
Cat:
SL2533R-FITC
Species Reactivity：
Mouse,Rat,(predicted: Human,Dog,Pig,Cow,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human Versican
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
370kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Function:
May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.

Subunit:
Interacts with FBLN1 (By similarity).

Subcellular Location:
Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Cerebral white matter and plasma. Isoform V0 and isoform V1 are expressed in normal brain, gliomas, medulloblastomas, schwannomas, neurofibromas, and meningiomas. Isoform V2 is restricted to normal brain and gliomas. Isoform V3 is found in all these tissues except medulloblastomas.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium.

DISEASE:
Defects in VCAN are the cause of Wagner syndrome type 1 (WGN1) [MIM:14640]. WGN is a dominantly inherited vitreoretinopathy characterized by an optically empty vitreous cavity with fibrillary condensations and a preretinal avascular membrane. Other optical features include progressive chorioretinal atrophy, perivascular sheating, subcapsular cataract and myopia. Systemic manifestations are absent in WGN.

Similarity:
Belongs to the aggrecan/versican proteoglycan family.
Contains 1 SLCtype lectin domain.
Contains 2 EGF-like domains.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Contains 2 Link domains.
Contains 1 Sushi (CCP/SCR) domain.

Database links:

Entrez Gene: 1462 Human

Entrez Gene: 13003 Mouse

Entrez Gene: 114122 Rat

Omim: 118661 Human

SwissProt: P13611 Human

SwissProt: Q62059 Mouse

SwissProt: Q9ERB4 Rat

Unigene: 68761 Human

Unigene: 715773 Human

Unigene: 158700 Mouse

Unigene: 410783 Mouse

Unigene: 35666 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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