background:
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.
Subunit:
Homodimer. Interacts with PILRB.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Natural killer cells.
Similarity:
Belongs to the CD99 family.
Database links:
Entrez Gene: 4267 Human
Entrez Gene: 673094 Mouse
Omim: 313470 Human
SwissProt: P14209 Human
SwissProt: Q8VCN6 Mouse
Unigene: 653349 Human
Unigene: 423040 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD99（P30/32MIC2）是一种跨膜蛋白，为MIC2基因产物。分布于淋巴细胞、胸腺皮质细胞、卵巢的颗粒细胞、胰岛细胞和睾丸支持细胞。
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