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Rabbit Anti-KCNC3/FITC Conjugated antibody
background:
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq].
Function:
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Subunit:
Heterotetramer of potassium channel proteins.
Subcellular Location:
Membrane; Multi-pass membrane protein.
DISEASE:
Spinocerebellar ataxia 13 (SCA13) [MIM:605259]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily.
Database links:
Entrez Gene: 3748 Human
Entrez Gene: 16504 Mouse
Entrez Gene: 117101 Rat
Omim: 176264 Human
SwissProt: Q14003 Human
SwissProt: Q63959 Mouse
SwissProt: Q01956 Rat
Unigene: 467146 Human
Unigene: 40312 Mouse
Unigene: 9885 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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