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Rabbit Anti-TNFSF4/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq]
Function:
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subunit:
Homotrimer (Probable).
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Detected in T-cell lines, but not in a macrophage cell line.
Similarity:
Belongs to the tumor necrosis factor family.
Database links:
Entrez Gene: 7292 Human
Entrez Gene: 22164 Mouse
Entrez Gene: 89814 Rat
Omim: 603594 Human
SwissProt: P23510 Human
SwissProt: P43488 Mouse
SwissProt: Q9Z2P3 Rat
Unigene: 181097 Human
Unigene: 4994 Mouse
Unigene: 30043 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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