Rabbit Anti-TNFSF18/FITC Conjugated antibody

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Tumor necrosis factor ligand superfamily member 18; AITRL; GITRL; hGITRL; TL6; Activation inducible TNF related ligand; AITR ligand ; AITRL; GITR ligand; ; Glucocorticoid induced TNF related ligand; Glucocorticoid induced TNFR related protein ligand; MGC1

Cat:

SL2456R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,)

Immunogen：

KLH conjugated synthetic peptide derived from human TNFSF18

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

23kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq].

Function:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.

Subunit:
Homodimer. Homotrimer.

Subcellular Location:
Cell membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Similarity:
Belongs to the tumor necrosis factor family.

Database links:

Entrez Gene: 8995 Human

Entrez Gene: 48873 Mouse

Omim: 603898 Human

SwissProt: Q9UNG2 Human

SwissProt: Q7TS55 Mouse

Unigene: 248197 Human

Unigene: 276823 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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