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Rabbit Anti-CCL3/FITC Conjugated antibody
background:
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Function:
Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in lung, spleen, and pancreas.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:
Entrez Gene: 6348 Human
Entrez Gene: 20302 Mouse
Entrez Gene: 25542 Rat
Omim: 182283 Human
SwissProt: P10147 Human
SwissProt: P10855 Mouse
SwissProt: P50229 Rat
Unigene: 514107 Human
Unigene: 1282 Mouse
Unigene: 10139 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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