Rabbit Anti-CD137/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-CD137/FITC Conjugated antibody

Tumor necrosis factor receptor superfamily member 9; Tnfrsf9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; Cd137; CDw137; CD 137; CD137 antigen; Induced by

Cat:

SL2449R-FITC

Species Reactivity：

Human,(predicted: Mouse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD137

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

25kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit:
Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on the surface of activated T-cells.

Similarity:
Contains 4 TNFR-Cys repeats.

Database links:

Entrez Gene: 724 Human

Omim: 602250 Human

SwissProt: Q07011 Human

Unigene: 654459 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD137属于肿瘤坏死因子超家族成员，是可诱导的T细胞共刺激受体，表达于CD4 + 和CD8 + T细胞、活化的自然杀伤细胞（natural killercell，NK）和树突状细胞,CD137可抑制T细胞增殖，诱发细胞凋亡。

Product Feedback Wall