Rabbit Anti-ZNF217/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-ZNF217/FITC Conjugated antibody

zinc finger protein 217; ZABC 1; ZABC1; ZN 217; ZN217; ZNF 217; 4933431C08Rik; AW987152; Gm562; Zfp217; ZN217_HUMAN .

Cat:

SL2510R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human ZNF217

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

115kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, SHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression.

Function:
Binds to the promoters of target genes and functions as epressor. Promotes cell proliferation and antagonizes cell death. romotes phosphorylation of AKT1 at 'Ser-473'.

Subunit:
Component of a histone deacetylase complex that contains DAC2, KDM1A, CTBP1 and ZNF217. May be a component of a SHC histone eacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, DM1A, RCOR1/CoREST, PHF21A/SHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and TF2I. Interacts with CTBP1 and CTBP2.

Subcellular Location:
Nucleus (Probable).

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 7 C2H2-type zinc fingers.

Database links:

Entrez Gene: 7764 Human

Omim: 602967 Human

SwissProt: O75362 Human

Unigene: 155040 Human

Unigene: 711564 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall