Rabbit Anti-Pleiotrophin/FITC Conjugated antibody

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pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite Growth Promoting Factor 1; OSF-1; osteoblast-specific fa

Cat:

SL2444R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PTN

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

15kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells.

Function:
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.

Subunit:
Interacts with ALK and NEK6.

Subcellular Location:
Secreted.

Tissue Specificity:
Osteoblast and brain.

Post-translational modifications:
Phosphorylated by NEK6.

Similarity:
Belongs to the pleiotrophin family.

Database links:

Entrez Gene: 5764 Human

Entrez Gene: 19242 Mouse

Entrez Gene: 24924 Rat

Omim: 162095 Human

SwissProt: P21246 Human

SwissProt: P63089 Mouse

SwissProt: P63090 Rat

Unigene: 371249 Human

Unigene: 279690 Mouse

Unigene: 1653 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

多效生长因子(pleiotrophin）是一种分泌性的生长因子,具有促进肿瘤细胞的增殖与迁移，对肿瘤血管的生成有促进作用。

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