Home
>
Product
>
Antibody
>
Rabbit Anti-BAFF/FITC Conjugated antibody
background:
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [provided by RefSeq].
Function:
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Subunit:
Belongs to the tumor necrosis factor family.
Subcellular Location:
Secreted and Cell membrane.
Tissue Specificity:
Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas.
Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing.
Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
Similarity:
Belongs to the tumor necrosis factor family.
Database links:
Entrez Gene: 10673 Human
Entrez Gene: 4899 Mouse
Omim: 603969 Human
SwissProt: Q9Y275 Human
SwissProt: Q9WU72 Mouse
Unigene: 525157 Human
Unigene: 596110 Human
Unigene: 28835 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|