Rabbit Anti-AVEN/FITC Conjugated antibody

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1700013A01Rik; 1700056A21Rik; mAven L; mAven S; MGC124011; Apoptosis caspase activation inhibitor; Cell death regulator Aven; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2; AVEN_HUMAN

Cat:

SL2438R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Pig,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human AVEN

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

38kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients.

Function:
Protects against apoptosis mediated by Apaf-1

Subunit:
Binds Apaf-1, BCL-2 and BAD (Bcl-xl)

Subcellular Location:
Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes.

Tissue Specificity:
Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas.

Database links:

Entrez Gene: 57099 Human

Entrez Gene: 74268 Mouse

Entrez Gene: 311299 Rat

Omim: 605265 Human

SwissProt: Q9NQS1 Human

SwissProt: Q9D9K3 Mouse

Unigene: 555966 Human

Unigene: 315125 Mouse

Unigene: 436657 Mouse

Unigene: 145049 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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