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Home > Product > Antibody > Rabbit Anti-PTP4A2/FITC Conjugated antibody
Protein tyrosine phosphatase type IV A protein 2; Protein-tyrosinephosphatase 4a2; Protein-tyrosine phosphatase of regeneratingliver 2; PRL-2; PRL2; PRL 2; TP4A2_HUMAN; BM 008; EC 3.1.3.48; HH 13; HH13; HH7 2; HU PP 1; HUPP 1; HUPP1; OV 1; OV1; phosphatas
Cat:
SL0644R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,)
Immunogen：
KLH conjugated synthetic peptide derived from human PTP4A2
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
19kDa
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Product PDFs
Datasheet:


background:
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic SLCterminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its SLCterminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

Function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB.

Subunit:
In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB.

Subcellular Location:
Cell membrane. Early endosome. Cytoplasm.

Tissue Specificity:
Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue.

Post-translational modifications:
Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol.

Similarity:
Belongs to the protein-tyrosine phosphatase family.
Contains 1 tyrosine-protein phosphatase domain.

Database links:

Entrez Gene: 8073 Human

Entrez Gene: 19244 Mouse

Entrez Gene: 85237 Rat

Omim: 601584 Human

SwissProt: Q12974 Human

SwissProt: O70274 Mouse

SwissProt: Q6P9X4 Rat

Unigene: 470477 Human

Unigene: 193688 Mouse

Unigene: 167750 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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