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Rabbit Anti-KCNH1/FITC Conjugated antibody
background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function:
Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts.
Subunit:
The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
Similarity:
Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily.
Contains 1 cyclic nucleotide-binding domain.
Contains 1 PAC (PAS-associated SLCterminal) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
Database links:
Entrez Gene: 3756 Human
Entrez Gene: 16510 Mouse
Entrez Gene: 65198 Rat
Omim: 603305 Human
SwissProt: O95259 Human
SwissProt: Q60603 Mouse
SwissProt: Q63472 Rat
Unigene: 553187 Human
Unigene: 4489 Mouse
Unigene: 11071 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KCNH1钾通道蛋白在调控细胞增殖和细胞周期进程中起重要作用。Eag1是膜蛋白, 参与细胞信号转导, 在正常组织和恶性肿瘤中有独特的表达特点.
一些离子通道如钾、钙、氯、钠等通道与肿瘤相关,特别是钾通道与肿瘤的关系最为密切。钾通道是细胞膜上种类最多、最为复杂的一类离子通道,它存在于多种细胞中,是细胞膜电位的重要控制因素。
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