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Rabbit Anti-DLK1/FITC Conjugated antibody
background:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010].
Function:
May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation.
Subunit:
Monomer.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary and, to a lesser degree, in adult kidney, muscle, thymus and heart.
Post-translational modifications:
N- and O-glycosylated.
Similarity:
Contains 6 EGF-like domains.
Database links:
Entrez Gene: 8788 Human
Entrez Gene: 13386 Mouse
Entrez Gene: 114587 Rat
Omim: 176290 Human
SwissProt: P80370 Human
SwissProt: Q09163 Mouse
Unigene: 533717 Human
Unigene: 157069 Mouse
Unigene: 14547 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
穿膜蛋白DLK1又称肝癌相关基因,是表皮生长因子(EGF)家族的成员之一,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经内分泌细胞及其肿瘤细胞中表达, DLK1在神经内分泌轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
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