Rabbit Anti-NCR2/FITC Conjugated antibody

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Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Lymphocyte antigen 95 (activating NK receptor; NK p44); Natural cytotoxicity triggering receptor 2; Natural killer cell p44-related protein; NK cell activa

Cat:

SL2420R-FITC

Species Reactivity：

Human,

Immunogen：

KLH conjugated synthetic peptide derived from human CD336

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

28kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1

Function:
Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.

Subunit:
Interacts with TYROBP/DAP12.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential).

Tissue Specificity:
Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells.

Similarity:
Belongs to the natural cytotoxicity receptor (NCR) family.
Contains 1 Ig-like (immunoglobulin-like) domain.

Database links:

Entrez Gene: 9436 Human

GenBank: NM_004828 Human

Omim: 604531 Human

SwissProt: O95944 Human

Unigene: 194721 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

细胞毒性受体家族（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。

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