background:
Natural killer (NK) cells are lymphocytes that can mediate the lysis of certain tumor cells and virus infected cells without being previously activated. They can also regulate specific humoral and cell mediated immunity. NK cells preferentially express several calcium dependent (C type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C type lectin genes preferentially expressed on NK cells.
Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subunit:
Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Natural killer cells.
Similarity:
Contains 1 SLCtype lectin domain.
Database links:
Entrez Gene: 3822 Human
Omim: 602891 Human
SwissProt: Q9GME8 Chimpanzee
SwissProt: P26717 Human
SwissProt: Q9MZK6 Rhesus monkey
Unigene: 591157 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自然杀伤细胞活化性受体2C
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