Rabbit Anti-SLC10A1/FITC Conjugated antibody

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Na+/taurocholate Cotransporting Polypeptide; Na(+)/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na / bile acid cotransporter; Na / taurocholate transport protein; Na(+)/taurocholate transport protein; NTCP; NTCP1; Sodium/taurocholate c

Cat:

SL1958R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Dog,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human NTCP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

Flow-Cyt=1:50-200ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

38kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization(SLC10A2; MIM 601295), and the other being found in the basolateral membranes of hepatocytes (SLC10A1).[supplied by OMIM]

Function:
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Liver and kidney

Similarity:
Belongs to the sodium:bile acid symporter family.

Database links:

Entrez Gene: 6554 Human

Entrez Gene: 20493 Mouse

Entrez Gene: 24777 Rat

Omim: 182396 Human

SwissProt: Q14973 Human

SwissProt: O08705 Mouse

SwissProt: P26435 Rat

Unigene: 952 Human

Unigene: 341781 Mouse

Unigene: 9913 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NTCP（钠离子/牛磺胆酸共转运蛋白）(钠离子-牛磺胆酸共转运多肽)Na+/taurocholate Cotransporting Polypeptide是肝脏的胆汁酸盐吸收主要是钠离子依赖性转运子NTCP介导的，主要吸收牛磺胆酸，是肝细胞特有的一种转运载体，分布在肝细胞基侧膜在肝小叶和肝的腺泡表达较多。
有学者认为：NTCP是乙肝病毒的细胞表面受体分子，是HBV和HDV的功能受体，这些研究将有待于科研人员的进一步证实。

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