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Rabbit Anti-MCM3/FITC Conjugated antibody
background:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Subunit:
Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5 (By simililarity). Associated with the replication-specific DNA polymerase alpha. Interacts with MCMBP.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the MCM family.
Contains 1 MCM domain.
Database links:
Entrez Gene: 4172 Human
Entrez Gene: 17215 Mouse
Entrez Gene: 316273 Rat
Omim: 602693 Human
SwissProt: P25205 Human
SwissProt: P25206 Mouse
Unigene: 179565 Human
Unigene: 4502 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MCM3也是MCMs1-7个家族中重要的一员,与生物体DNA复制过程密切相关。
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