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Rabbit Anti-CLEC5A/FITC Conjugated antibody
background:
This gene encodes a member of the SLCtype lectin/SLCtype lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein interacts with dnax-activation protein 12 and may play a role in cell activation. Alternative splice variants have been described but their full-length sequence has not been determined. [provided by RefSeq].
Function:
Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation. Critical macrophage receptor for dengue virus serotypes 1-4. The binding of dengue virus to CLEC5A triggers signaling through phosphylation of TYROBP, this interaction does not result in viral entry but stimulates proinflammatory cytokine release.
Subunit:
Monomer. Homodimer. The majority of CLEC5A is expressed as a monomeric form on macrophages. Interacts with TYROBP/DAP12. The interaction with TYROBP is required for CLEC5 cell surface expression. Interacts with HCST/DAP10. Forms an CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP.
Subcellular Location:
Cell membrane; Single-pass type II membrane protein.
Tissue Specificity:
Expressed in peripheral blood monocytes and in the monocyte/macrophage cell lines U937 and MonoMac6, but not in cell lines of other origins. Expression is down-regulated when monocytes differentiate into dendritic cells.
Post-translational modifications:
N-glycosylated. Contains sialic acid residues.
DISEASE:
Note=Involved in the pathogenetic mechanisms of Japanese encephalitis virus (JEV) infection of the brain. JEV infection of young mice results in increased expression of CLEC5A in spleen and brain with consequent activation of proinflammatory cytokines secretion.
Similarity:
Contains 1 SLCtype lectin domain.
Database links:
Entrez Gene: 2721 Human
Entrez Gene: 23845 Mouse
Entrez Gene: 679787 Rat
Omim: 604987 Human
SwissProt: Q9NY25 Human
SwissProt: Q9R007 Mouse
Unigene: 446235 Human
Unigene: 103765 Mouse
Unigene: 218435 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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