background:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Function:
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Subunit:
Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.
Subcellular Location:
Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.
Tissue Specificity:
Highly expressed in endothelial cells, aortic intima and lung. Expressed at low level in other tissues.
Post-translational modifications:
N-glycosylated.
Similarity:
Contains 1 SLCtype lectin domain.
Database links:
Entrez Gene: 4973 Human
Entrez Gene: 108078 Mouse
Entrez Gene: 140914 Rat
Omim: 602601 Human
SwissProt: P78380 Human
SwissProt: Q9EQ09 Mouse
SwissProt: Q9XTA8 Rabbit
SwissProt: O70156 Rat
Unigene: 412484 Human
Unigene: 293626 Mouse
Unigene: 87449 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LOX-1(Lectin-like Ox-LDL receptor 1)即氧化低密度脂蛋白的内皮受体，是清除受体或称清道夫受体（Scavenger Receptor,SR）家族的一种，LOX-1作为氧化低密度脂蛋白的天然配体，与脂质代谢有关。
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