Rabbit Anti-TNFRSF12A/FITC Conjugated antibody

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CD 266; CD266; CD266 antigen; TWEAKR; FGF inducible 14; FGF-inducible 14; Fibroblast growth factor inducible immediate early response protein 14; Fibroblast growth factor-inducible immediate-early response protein 14; FN 14; FN14; TNFRSF 12A; TNFRSF12A; T

Cat:

SL2493R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TNFRSF12A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

11kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
TWEAK (otherwise known as TNFRSF12A, Tumor necrosis factor receptor superfamily member 12A), is a member of the TNF family and was first described as a weak inducer of apoptosis in some cell types. It is thought to promote angiogenesis and the proliferation of endothelial cells as well as modulating cellular adhesion to matrix proteins. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library.

Function:
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.

Subunit:
Associates with TRAF1 and TRAF2, and probably also with TRAF3.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.

Similarity:
Contains 1 TNFR-Cys repeat.

Database links:

Entrez Gene: 51330 Human

Entrez Gene: 27279 Mouse

Entrez Gene: 302965 Rat

Omim: 605914 Human

SwissProt: Q9NP84 Human

SwissProt: Q9CR75 Mouse

Unigene: 355899 Human

Unigene: 28518 Mouse

Unigene: 105040 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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