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Rabbit Anti-NKG2A/FITC Conjugated antibody
background:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a SLCtype lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Function:
Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
Subunit:
Can form disulfide-bonded heterodimer with CD94.
Subcellular Location:
Membrane; Single-pass type II membrane protein.
Tissue Specificity:
Natural killer cells.
Similarity:
Contains 1 SLCtype lectin domain.
Database links:
Entrez Gene: 3821 Human
Entrez Gene: 16641 Mouse
Omim: 161555 Human
SwissProt: P26715 Human
Unigene: 512576 Human
Unigene: 56899 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
自然杀伤细胞活化性受体2A
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