Rabbit Anti-TNFAIP1/FITC Conjugated antibody

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tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial); BACD2_HUMAN; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; B

Cat:

SL2104R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,)

Immunogen：

KLH conjugated synthetic peptide derived from human TNFAIP1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

35kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008].

Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.

Subcellular Location:
Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.

Post-translational modifications:
Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.

Similarity:
Belongs to the BACURD family.
Contains 1 BTB (POZ) domain.

Database links:

Entrez Gene: 7126 Human

Entrez Gene: 21927 Mouse

Entrez Gene: 287543 Rat

Omim: 191161 Human

SwissProt: Q13829 Human

SwissProt: O70479 Mouse

SwissProt: Q7TNY1 Rat

Unigene: 76090 Human

Unigene: 386774 Mouse

Unigene: 18199 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

TNFAIP1 protein是第一个被鉴定受肿瘤坏死因子α诱导的蛋白,实验证明TNFAIP1 蛋白可能参与DNA复制、合成、细胞凋亡以及人类的各种疾病等重要生理过程，但还有一些功能不清。

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