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Rabbit Anti-VEGF-B/FITC Conjugated antibody
background:
This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Subunit:
Homodimer; disulfide-linked. Can also form heterodimer with VEGF.
Subcellular Location:
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Post-translational modifications:
VEGF-B186 is O-glycosylated.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 7423 Human
Entrez Gene: 22340 Mouse
Entrez Gene: 89811 Rat
Omim: 601398 Human
SwissProt: P49765 Human
SwissProt: P49766 Mouse
SwissProt: O35485 Rat
Unigene: 78781 Human
Unigene: 15607 Mouse
Unigene: 198550 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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