Rabbit Anti-WNK3/FITC Conjugated antibody

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Serine/threonine-protein kinase WNK3; WNK lysine deficient protein kinase 3; Protein kinase with no lysine 3; Protein kinase, lysine-deficient 3; Wnk3; RGD1563131; KIAA1566; PRKWNK 3; PRKWNK-3; PRKWNK3; Protein kinase lysine deficient 3; Protein kinase ly

Cat:

SL1945R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human WNK3 protein

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

198kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
WNK3 (WNK lysine deficient protein kinase 3) belongs to the serine/threonine protein kinase family. It lacks the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. A conserved lysine in subdomain I is thought to provide this function. WNK3 activates Na-(K)-Cl cotransporters by increasing their phosphorylation and appears to be a crucial component of the kinase/phosphatase signaling pathway that coordinately regulates the Cl– influx and efflux branches of the SLC12A cotransporter family.

Subunit:
Interacts with WNK1 and WNK4.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain, lung, kidney, liver and pancreas, and in fetal tissues including placenta, fetal brain, lung and kidney. Very low levels of expression were also detected in fetal heart, thymus, liver and spleen. Isoform 1 is brain-specific. Isoform 3 is kidney-specific.

Similarity:
BBelongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 65267 Human

Omim: 300358 Human

SwissProt: Q9BYP7 Human

Unigene: 92423 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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