Rabbit Anti-Vitronectin/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Vitronectin/FITC Conjugated antibody

Vitronectin; Complement S Protein; Epibolin; S Protein; Serum Spreading Factor; V75; Vitronectin V10 subunit; VN; VNT; VTN; S-protein; Serum-spreading factor; V75; Vitronectin V10 subunit; VTNC_HUMAN.

Cat:

SL1932R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human Vitronectin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

9/52kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases.

Function:
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity).

Subunit:
Monomer. Interacts with SERPINE1/PAI1 (By similarity).

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Plasma.

Post-translational modifications:
Sulfated on 2 tyrosine residues (By similarity).
N- and O-glycosylated (By similarity).
It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.

Similarity:
Contains 4 hemopexin-like domains.
Contains 1 SMB (somatomedin-B) domain.

Database links:

Entrez Gene: 7448 Human

Entrez Gene: 22370 Mouse

Entrez Gene: 29169 Rat

Omim: 193190 Human

SwissProt: P04004 Human

SwissProt: P29788 Mouse

Unigene: 2257 Human

Unigene: 3667 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall