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Rabbit Anti-Rad52/FITC Conjugated antibody
background:
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. [provided by RefSeq, Jul 2008]
Function:
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.
Subunit:
The full-length protein forms heptameric rings. Interacts with ABL1.
Subcellular Location:
Nucleus (Potential).
Post-translational modifications:
Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
Similarity:
Belongs to the RAD52 family.
Database links:
Entrez Gene: 5893 Human
Omim: 600392 Human
SwissProt: P43351 Human
Unigene: 410355 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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