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Rabbit Anti-Moesin/FITC Conjugated antibody
background:
Moesin is a member of the ERM (Ezrin-Radixin-Moesin) protein family, which possesses structural and probably functional relationships; they function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane and are all localized to the submembranous cytoskeleton.
Moesin is widely expressed in different tissues in cells, where it is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signalling and for cell movement.
Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.
Subunit:
In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation. Binds SLC9A3R1. Interacts with PPP1R16B. Interacts with PDZD8. Interacts with SELPLG and SYK; mediates the activation of SYK by SELPLG.
Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.
Tissue Specificity:
In all tissues and cultured cells studied.
Post-translational modifications:
Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and SLCterminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). Phosphorylation on Thr-558 by STK10 negatively regulates lymphocyte migration and polarization.
Similarity:
Contains 1 FERM domain.
Database links:
Entrez Gene: 4478 Human
Entrez Gene: 17698 Mouse
Entrez Gene: 81521 Rat
Omim: 309845 Human
SwissProt: P26038 Human
SwissProt: P26041 Mouse
SwissProt: O35763 Rat
Unigene: 87752 Human
Unigene: 138876 Mouse
Unigene: 2762 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Moesin是细胞骨架与细胞膜之间的连接蛋白,对细胞膜区域的整合和稳定性起到结构和功能调控的作用.通过连接细胞骨架和细胞膜。Moesin对细胞黏附、形态、分化、运动等起到重要调节作用。膜突蛋白早先被鉴定为一种硫酸乙酰肝素的可能受体和细胞骨架的连接蛋白，能稳定细胞表面的微绒毛、丝足和层形足板。膜-细胞骨架连接蛋白的埃兹蛋白-根蛋白-膜突蛋白（ERM）家族的成员都具有与质膜和肌动蛋白细胞骨架分别相连的氨基端和羧基端结构域。
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