Rabbit Anti-Midkine/FITC Conjugated antibody

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Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN.

Cat:

SL1849R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Fruit Fly,)

Immunogen：

KLH conjugated synthetic peptide derived from human Midkine

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

13.4kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.

Function:
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).

Subunit:
Homodimer. Interacts with ALK.

Subcellular Location:
Secreted.

Similarity:
Belongs to the pleiotrophin family.

Database links:

Entrez Gene: 280852 Cow

Entrez Gene: 4192 Human

Entrez Gene: 17242 Mouse

Entrez Gene: 81517 Rat

Omim: 162096 Human

SwissProt: P21741 Human

SwissProt: P12025 Mouse

SwissProt: Q9R1S9 Rat

Unigene: 21528 Cow

Unigene: 82045 Human

Unigene: 906 Mouse

Unigene: 17447 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

中期因子(midkine, MK)具有多种生物学功能: 可促进神经轴突的生长和各种胚胎神经元的存活,做为一种有丝分裂原,与肿瘤的发生密切相关，MK还有较强的促血管生成特性, 经研究证实, MK可促进内皮细胞增殖并提高血管的密度，在多种肿瘤组织和肿瘤患者的血清中的水平都明显升高。MK和多向促激素(p leiotro2 phin, PTN)同属于一类新的结合肝素的生长因子家族。

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