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Rabbit Anti-LRIG2/FITC Conjugated antibody
background:
LRIG2 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG2 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Cytoplasm.
Tissue Specificity:
Detected in all tissues analyzed.
Similarity:
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 15 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Database links:
Entrez Gene: 9860 Human
Omim: 608869 Human
SwissProt: O94898 Human
Unigene: 448972 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LRIG1属于LRIGs基因家族。LRIGs是新发现的一类基因,在哺乳动物体内广泛存在,目前发现该家族至少包括三个成员:LRIG1、LRIG2和LRIG3,是一类结构相似的跨膜糖蛋白,该蛋白人、鼠的同源性较高。
目前在肿瘤方面的研究较多,有研究认为:LRIG1是通过下调EGFR的表达来抑制其下游重要信号传导通路的激活而发挥抑癌作用,LRIG1在抑制肿瘤转移中具有重要作用。
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