Rabbit Anti-PTGEs/Prostaglandin E Synthase/FITC Conjugated antibody

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Glutathione S transferase 1 like 1; MGC10317; MGST IV; MGST1 L1; MGST1 like 1; MGST1-L1; MGST1L1; MGSTIV; Microsomal glutathione S transferase 1 like 1; Microsomal glutathione S-transferase 1-like 1; Microsomal prostaglandin E synthase 1; Microsomal prost

Cat:

SL376R-FITC

Species Reactivity：

Human,(predicted: Mouse,Rat,Guinea Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human PTGEs

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

17kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Prostaglandin E synthase catalyses conversion of COX derived PGH2 to PGE2. It is a member of the MAPEG family. It may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain during inflammatory responses.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Function:
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).

Subunit:
Homotrimer.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the MAPEG family.

Database links:

Entrez Gene: 417193 Chicken

Entrez Gene: 282019 Cow

Entrez Gene: 96698 Dog

Entrez Gene: 9536 Human

Entrez Gene: 64292 Mouse

Entrez Gene: 59103 Rat

Entrez Gene: 544666 Zebrafish

Omim: 605172 Human

SwissProt: O14684 Human

SwissProt: Q9JM51 Mouse

Unigene: 146688 Human

Unigene: 28768 Mouse

Unigene: 7730 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PTGES由白介素-1β诱导产生，可能参与P53诱导的凋亡过程。

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