background:
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene.
Function:
Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism.
Subunit:
Binds MYBBP1A, which inhibits transcriptional activation by this protein. Interacts with PRDM16. Interacts with LRPPRC. Homooligomer. Interacts with LPIN1.
Subcellular Location:
Nucleus.
Tissue Specificity:
Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
Post-translational modifications:
hosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
Database links:
Entrez Gene: 422815 Chicken
Entrez Gene: 338446 Cow
Entrez Gene: 479127 Dog
Entrez Gene: 10891 Human
Entrez Gene: 19017 Mouse
Entrez Gene: 497232 Pig
Entrez Gene: 83516 Rat
Omim: 604517 Human
SwissProt: Q865B7 Cow
SwissProt: Q9UBK2 Human
SwissProt: O70343 Mouse
SwissProt: Q865B6 Pig
SwissProt: Q9QYK2 Rat
Unigene: 527078 Human
Unigene: 259072 Mouse
Unigene: 19172 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PGSLC1α是一个新发现的转录激活因子,起到高游离脂肪酸刺激胰岛α细胞分泌的重要调控作用。
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