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Rabbit Anti-NPTN/FITC Conjugated antibody
background:
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2009]
Function:
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Potential). Note=Enriched at postsynaptic density (By similarity).
Tissue Specificity:
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).
Similarity:
Contains 3 Ig-like (immunoglobulin-like) domains.
Database links:
Entrez Gene: 27020 Human
Entrez Gene: 2064 Mouse
Entrez Gene: 56064 Rat
Omim: 612820 Human
SwissProt: Q9Y639 Human
SwissProt: P97300 Mouse
SwissProt: P97546 Rat
Unigene: 713221 Human
Unigene: 15125 Mouse
Unigene: 37476 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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