Rabbit Anti-Met Enkephalin/FITC Conjugated antibody

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Met-enkephalin; [Met]enkephalin; Enkephalin; M-ENK; Methionine Enkephalin; OGF; Opioid growth factor; PENK; PPA; Proenkephalin A; Proenkephalin; M enk; PE; PENK-A; PENK_HUMAN.

Cat:

SL1759R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,)

Immunogen：

KLH conjugated Met Enkephalin peptide (Tyr-Gly-Gly-Phe-Met)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

0.5kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Enkephalin and enkephalin-like peptides have been detected in many animal species. In mammals these opioid pentapeptides are cleaved from a common precursor molecule which is expressed in a number of cell types, including neurons and endocrine cells associated with the sympathetic nervous system where they are often co-stored with catecholamines. They are known to be endogenous ligands for Sopioid receptors and are known to mediate analgesia at the spinal level.
Met-enkephalin (tyr-gly-gly-phe-met) and leu-enkephalin (tyr-gly-gly-phe-leu) are pentapeptides which compete with and mimic the effects of opiate drugs. Although interest in enkephalins stems largely from their possible role in the brain, the richest source of these peptides is the adrenal gland. The amino acid sequence shows that the precursor is 267 amino acids long and contains 6 interspersed Met-enkephalin sequences and 1 Leu-enkephalin sequence. The precursor does not contain the sequences of dynorphin, alpha-neo-endorphin or beta-endorphin. (Because of structural similarities it had been postulated that beta-endorphin is precursor of Met-enkephalin, and that dynorphin or alpha-neo-endorphin is precursor of Leu-enkephalin.)

Function:
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

Subcellular Location:
Secreted.

Post-translational modifications:
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.

Similarity:
Belongs to the opioid neuropeptide precursor family.

Database links:

Entrez Gene: 5179 Human

Entrez Gene: 18619 Mouse

Entrez Gene: 29237 Rat

Omim: 131330 Human

SwissProt: P01210 Human

SwissProt: P4405 Mouse

SwissProt: P04094 Rat

Unigene: 339831 Human

Unigene: 475097 Mouse

Unigene: 10015 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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