Rabbit Anti-ERCC1/FITC Conjugated antibody

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Excision Repair Cross Complementing 1; DNA excision repair protein ERCC-1; COFS4; UV20; DNA excision repair protein ERCC1; ERCC 1; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1; Excision repair protein; UV 20; UV20;D

Cat:

SL1726R-FITC

Species Reactivity：

Human,Mouse,Rat,(predicted: Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human ERCC1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

36kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

Subunit:
Heterodimer composed of ERCC1 and XPF/ERRC4.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the ERCC1/RAD10/SWI10 family.

Database links:

Entrez Gene: 2067 Human

Entrez Gene: 13870 Mouse

Entrez Gene: 292673 Rat

Omim: 126380 Human

SwissProt: P07992 Human

SwissProt: P07903 Mouse

Unigene: 435981 Human

Unigene: 280913 Mouse

Unigene: 764 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ERCC1蛋白是动物内重要的DNA修复基因家族成员之一。在人体内它的低表达往往伴随着基因不稳定性增加,从而产生肿瘤恶性变的发生。ERCC1是损伤DNA核苷酸切除修复中高度保守的切除性核酶。在哺乳动物的核苷酸切除修复中，XPG负责切割DNA损伤区域的3’端，而ERCC1-XPF复合物在5’端打开切口。目前初步的研究表明，癌瘤中的ERCC1蛋白表达程度越低，顺氯氨铂化疗的效果就越好。ERCC1蛋白阳性的患者，非化疗治疗的预后要好于接受化疗。

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