Home
>
Product
>
Antibody
>
Rabbit Anti-Plexin A1/FITC Conjugated antibody
background:
Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury.
Function:
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subunit:
Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2.
Subcellular Location:
Cell membrane (Probable); Single-pass type I membrane protein.
Tissue Specificity:
Detected in fetal brain, lung, liver and kidney.
Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.
Database links:
Entrez Gene: 5361 Human
Entrez Gene: 18844 Mouse
NCBI: NP_115618 Human
Omim: 601055 Human
SwissProt: Q9UIW2 Human
SwissProt: P70206 Mouse
Unigene: 432329 Human
Unigene: 549421 Human
Unigene: 3789 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Plexins是一种单途径、具有多向潜在功能的跨膜蛋白，为Sema-phorins（神经信号蛋白）家族的受体,PlexinA1蛋白主要定位于细胞质和细胞膜，Semaphorins的很多重要的生理作用均是通过Plexins信号传导来发挥作用的。PlexinA1在神经系统形成、心血管生成、胚胎发生和免疫反应等方面发挥重要作用。
|
|
