background:
The protein encoded by this gene contains a kinase domain most closely related to the cyclin-dependent protein kinases. The encoded kinase may activate cyclin-dependent kinase 2 and is involved in cell growth. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Dec 2009]
Function:
Required for high-level Shh responses in the developing neural tube. Together with BROMI, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
Subunit:
Monomer. Interacts with BROMI.
Subcellular Location:
Nucleus. Cytoplasm. Cell projection, cilium.
Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.
Database links:
Entrez Gene: 23552 Human
Entrez Gene: 105278 Mouse
Entrez Gene: 364666 Rat
Omim: 610076 Human
SwissProt: Q8IZL9 Human
SwissProt: Q9JHU3 Mouse
SwissProt: Q4KM34 Rat
Unigene: 522274 Human
Unigene: 74982 Mouse
Unigene: 7013 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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