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Rabbit Anti-CCR9/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. Two alternatively spliced transcript variants have been described.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in the thymus and low in lymph nodes and spleen.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 10803 Human
Entrez Gene: 12769 Mouse
Entrez Gene: 282832 Rat
Omim: 604738 Human
SwissProt: P51686 Human
SwissProt: Q9WUT7 Mouse
Unigene: 225946 Human
Unigene: 91140 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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