Home
>
Product
>
Antibody
>
Rabbit Anti-Cathepsin H/FITC Conjugated antibody
background:
The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in various cellular events such as peptide biosynthesis and protein degradation. The propeptide region of cathepsin H is highly homologous to other cathepsins. This region is thought to play a role in the processing of cysteine proteases. Cathepsin H is thought to be involved in several pathological conditions, including neuro degenerative disorders and cancer.
Function:
Important for the overall degradation of proteins in lysosomes.
Subunit:
Composed of a mini chain and a large chain. The large chain may be split into heavy and light chain. All chains are held together by disulfide bonds.
Subcellular Location:
Lysosome.
Similarity:
Belongs to the peptidase C1 family.
Database links:
Entrez Gene: 1512 Human
Entrez Gene: 25425 Rat
Omim: 116820 Human
SwissProt: P09668 Human
SwissProt: P00786 Rat
Unigene: 148641 Human
Unigene: 1997 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|