Home
>
Product
>
Antibody
>
Rabbit Anti-Calpain 2/FITC Conjugated antibody
background:
Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names.
The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin.
Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.
Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Subunit:
Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
Subcellular Location:
Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the peptidase C2 family.
Contains 1 calpain catalytic domain.
Contains 2 EF-hand domains.
Database links:
Entrez Gene: 824 Human
Entrez Gene: 12334 Mouse
Entrez Gene: 29154 Rat
Omim: 114230 Human
SwissProt: P17655 Human
SwissProt: O08529 Mouse
SwissProt: Q07009 Rat
Unigene: 350899 Human
Unigene: 19306 Mouse
Unigene: 6822 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钙蛋白酶2(calpain2)也是一族钙离子依赖性的、水解半胱氨酸的蛋白酶,广泛存在于全身各脏器组织中。钙蛋白酶参与不同细胞过程,包括细胞骨架和细胞膜附着的构型重建、不同的信号转导途径和细胞凋亡等.
|
|
